Semaglutide / Tirzepatide
“The It Couple”
The names you have definitely heard at brunch.
Last medically reviewed: June 2026
What I look like
The form and how it is used
Usually prefilled injector pens for a once-a-week shot, though compounded vial versions exist too. These are the most genuinely medical entries on this list.
My story
Where I came from
Both started in diabetes care and became household names for weight change. Semaglutide works on the GLP-1 pathway, and tirzepatide adds a second one (GIP), which is why people talk about them in the same breath.
What I bring to the table
What people explore me for
- Help regulate appetite and blood sugar
- Associated with significant weight change
- Studied and prescribed under medical supervision
My red flags
Side effects and cautions to know
- Nausea and other digestive upset
- Constipation
- Possible muscle loss without enough protein and strength work
- Gallbladder issues and specific contraindications
Where to find me
The honest version, not a shopping guide
These are real prescription medications that come with provider oversight, and that is exactly how they should be accessed. Compounded versions exist in a shifting legal gray zone, so the prescription route through a provider is the safe one.